Accumulation of lethal proteins for various percentiles. Accumulation of lethal proteins for various percentiles of degree (gray line), betweeness centrality (dashed line) or the STM signal transduction metric (solid line). The results are shown for the top 555 proteins obtained from the yeast PPI network and are ordered; the highest values of these metrics are closest to the origin.
Hwang et al. Algorithms for Molecular Biology 2006 1:24 doi:10.1186/1748-7188-1-24